Journal
JOURNAL OF CARDIAC FAILURE
Volume 21, Issue 7, Pages 586-593Publisher
CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
DOI: 10.1016/j.cardfail.2015.04.014
Keywords
Heart failure; inflammasome; inflammation
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Funding
- National Institutes of Health National Institute of Nursing Research [T32NR012714]
- Heart Failure Society of America Nursing Research Grant
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Patients with heart failure continue to suffer adverse health consequences despite advances in therapies over the past 2 decades. Identification of novel therapeutic targets that may attenuate disease progression is therefore needed. The inflammasome may play a central role in modulating chronic inflammation and in turn affecting heart failure progression. The inflammasome is a complex of intracellular interaction proteins that trigger maturation of proinflammatory cytokines interleukin-1 beta and interleukin-18 to initiate the inflammatory response. This response is amplified through production of tumor necrosis factor a and activation of inducible nitric oxide synthase. The purpose of this review is to discuss recent evidence implicating this inflammatory pathway in the pathophysiology of heart failure.
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