Journal
MICROBES AND INFECTION
Volume 2, Issue 8, Pages 907-913Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S1286-4579(00)00392-0
Keywords
bile; bile acids; gallbladder; efflux pump; enteric pathogen; resistance
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Enteric bacteria are resistant to the bactericidal effects of intestinal bile, but these resistance mechanisms are not: completely understood. It is becoming increasingly apparent that enteric bacteria have evolved to utilize bile as a signal for the temporal production of virulence factors and other adaptive mechanisms. A greater understanding of the resistance and response of bacteria to bile may assist the development of novel therapeutic, prevention, and diagnostic strategies to treat enteric and extraintestinal infections. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
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