Journal
JOURNAL OF CARDIAC FAILURE
Volume 21, Issue 4, Pages 300-306Publisher
CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
DOI: 10.1016/j.cardfail.2015.01.003
Keywords
Heart failure; brain-derived neurotrophic factor; exercise capacity; prognosis
Categories
Funding
- Ministry of Education, Science, and Culture [20117004, 21390236, 24659379]
- Grants-in-Aid for Scientific Research [21390236, 24659379, 20117004] Funding Source: KAKEN
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Background: Brain-derived neurotropic factor (BDNF) is involved in cardiovascular diseases as well as skeletal muscle energy metabolism and depression. We investigated whether serum BDNF level was associated with prognosis in patients with heart failure (HF). Methods and Results: We measured the serum BDNF level in 58 patients with HF (59.2 +/- 13.7 years old, New York Heart Association functional class I III) at baseline, and adverse events, including all cardiac deaths and HF rehospitalizations, were recorded during the median follow-up of 20.3 months. In a univariate analysis, serum BDNF levels were significantly associated with peak oxygen capacity (beta = 0.547; P = .003), anaerobic threshold (beta = 0.929; P = .004), and log minute ventilation/carbon dioxide production slope (beta = 10.15; P = .005), but not Patient Health Questionnaire scores (beta = 0.099; P = .586). A multivariate analysis demonstrated that serum BDNF level was an independent prognostic factor of adverse events (hazard ratio 0.41, 95% confidence interval 0.20-0.84; P = .003). The receiver operating characteristic curve demonstrated that low levels of BDNF (<17.4 ng/mL) were associated with higher rates of adverse events compared with high levels of BDNF (>= 17.4 ng/mL; log rank test: P < .001). Conclusions: Decreased serum BDNF levels were significantly associated with adverse outcomes in HF patients, suggesting that these levels can be a useful prognostic biomarker.
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