Journal
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
Volume 186, Issue 7-8, Pages 605-616Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s003590000133
Keywords
evolution; channel; receptor; molecular neuroethology
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Funding
- NINDS NIH HHS [NS17323, NS35631] Funding Source: Medline
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Ion channels and receptors play critical roles in shaping neuronal activity, and thus are appropriate targets for evolutionary change to generate new behaviors. In this review, the evolution and differentiation of the many voltage-gated ion channels and transmitter-activated receptors is summarized; these channels and receptors evolved very early, and with some exceptions all species with nervous systems use similar sets of channels and receptors. Several examples are given of mechanisms for species-specific behavioral evolution that arise from mutations involving the structure, alternative splicing, level of expression, targeting and modulation of these important neural proteins.
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