Journal
NATURE CELL BIOLOGY
Volume 2, Issue 7, Pages 392-398Publisher
NATURE RESEARCH
DOI: 10.1038/35017020
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Funding
- NIDDK NIH HHS [DK41415, DK48330, DK52005] Funding Source: Medline
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Agonist-evoked, intracellular Ca2+-signalling events are associated with active extrusion of Ca2+ across the plasma membrane, implying a local increase in Ca2+ concentration ([Ca2+]) at the extracellular face of the cell. The possibility that these external [Ca2+] changes may have specific physiological functions has received little consideration in the past. Here we show that, at physiological ambient [Ca2+], Ca2+ mobilization in one cell produces an extracellular signal that can be detected in nearby cells expressing the extracellular Ca2+-sensing receptor (CaR), a cell-surface receptor for divalent cations with a widespread tissue distribution. The Can may therefore mediate a universal form of intercellular communication that allows cells to be informed of the Ca2+-signalling status of their neighbours.
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