Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 110, Issue 1, Pages 214-216Publisher
BLACKWELL SCIENCE LTD
DOI: 10.1046/j.1365-2141.2000.02142.x
Keywords
chronic myeloid leukaemia; Philadelphia chromosome; BCR-ABL positive; 5 '-ABL deletion; FISH
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Inclusion of the BCR-ABL ES probe in routine cytogenetics led to the identification of a subgroup of Philadelphia positive (Ph+) chronic myeloid leukaemia patients characterized by a 5'-ABL deletion. This anomaly was observed in 5/51 cases (9.8%). Cytological and clinical data suggest that the 5'-ABL deletion may be associated with dysplastic features of polymorphonuclear cells and metamyelocytes and a short chronic phase duration.
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