Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 25, Issue 7, Pages 311-316Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0968-0004(00)01600-5
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As originally postulated in Crick's Adaptor hypothesis, the faithful synthesis of proteins from messenger RNA is dependent on the presence of perfectly acylated tRNAs. The hypothesis also suggested that each aminoacyl-tRNA would be made by a unique enzyme. Recent data have now forced a revision of this latter point, with an increasingly diverse array of enzymes and pathways being implicated in aminoacyl-tRNA synthesis. These unexpected findings have far-reaching implications for our understanding of protein synthesis and its origins.
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