4.4 Article

Positive correlation between virulence of Pseudomonas aeruginosa mutants in mice and insects

Journal

JOURNAL OF BACTERIOLOGY
Volume 182, Issue 13, Pages 3843-3845

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.182.13.3843-3845.2000

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Funding

  1. NIGMS NIH HHS [F32 GM018735, GM18735] Funding Source: Medline

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Strain PA14, a human clinical isolate of Pseudomonas aeruginosa, is pathogenic in mice and insects (Galleria mellonella). Analysis of 32 different PA14 mutants in these two hosts showed a novel positive correlation in the virulence patterns. Thus, G. mellonella is a good model system for identifying mammalian virulence factors of P. aeruginosa.

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