Journal
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
Volume 463, Issue 1, Pages 13-31Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S1383-5742(00)00041-7
Keywords
Comet assay; human biomonitoring; dietary supplementation; lifestyle; occupational exposure; environmetal pollution
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Human biomonitoring using the single cell gel electrophoresis (SCGE) or comet assay is a novel approach for the assessment of genetic damage in exposed populations. This assay enables the detection of various forms of DNA damage in individual cells with ease and speed and is, therefore, well suited to the analysis of a large group in a population. Here, application of SCGE assay in the identification of dietary protective factors, in clinical studies and in monitoring the risk of DNA damage resulting from occupational, environmental or lifestyle exposures is reviewed. Also, the comparative sensitivity of SCGE assay and conventional cytogenetic tests to detect genetic damage is discussed. Finally, strengths and shortcomings of the SCGE assay are addressed. (C) 2000 Elsevier Science B.V. All rights reserved.
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