Journal
EXPERIMENTAL GERONTOLOGY
Volume 35, Issue 4, Pages 445-451Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0531-5565(00)00112-1
Keywords
amyloid beta; metals; oxidative stress; hydrogen peroxide; neurodegeneration; antioxidants; superoxide dismutase
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Alzheimer's disease is characterized by signs of a major oxidative stress in the neocortex and the concomitant deposition of Amyloid beta (A beta). A beta is a metalloprotein that binds copper. and is electrochemically active. A beta converts molecular oxygen into hydrogen peroxide by reducing copper or iron, and this may lead to Fenton chemistry. Hydrogen peroxide is a freely permeable prooxidant that may be responsible for many of the oxidative adducts that form in the Alzheimer-affected brain. The electrochemical activity of various A beta species correlates with the peptides' neurotoxicity in cell culture, and participation in the neuropathology of Alzheimer's disease. These reactions present a novel target for Alzheimer therapeutics. (C) 2000 Elsevier Science Inc. All rights reserved.
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