Journal
TRENDS IN CARDIOVASCULAR MEDICINE
Volume 10, Issue 5, Pages 216-223Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S1050-1738(00)00063-3
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- NHLBI NIH HHS [R01 HL58081-01, P50 HL-O6H, R01 HL61543-01, HL-42250-10/10] Funding Source: Medline
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Recent studies have identified the importance of biologically active molecules such as neurohormones in disease progression in heart failure. More recently it has become apparent that in addition to neurohormones another portfolio of biologically active molecules termed cytokines are also expressed in the setting of heart failure. This article reviews recent clinical and experimental material which suggest that the cytokines such as tumor necrosis factor (TNF), interleukin-1 (IL-1) and interleukin-6 (IL-6) may represent another class of biologically active molecules that are responsible for the development and progression of heart failure. In addition, we also review the early results from clinical trials that have utilized various targeted anti-cytokine strategies in patients with heart failure. (C) 2001, Elsevier Science Inc.
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