Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 64, Issue 7, Pages 1459-1465Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.64.1459
Keywords
dietary nucleotides; intraepithelial lymphocytes; TCR gamma delta(+) T cells; interleukin-7; intestinal epithelial cells
Ask authors/readers for more resources
We have investigated the effects of dietary nucleotides on intraepithelial lymphocytes (IEL) and intestinal epithelial cells (IEC) in weanling mice. The proportion of T-cell receptor (TCR) gamma delta(+) IEL in BALB/c mice fed a diet supplemented with nucleotides (NT(+) diet) was significantly higher than that in mice fed the nucleotide-free diet, while the proportion of TCR alpha beta(+) IEL in NT(+) diet-fed mice was significantly decreased. The change of the TCR alpha beta(+)/TCR gamma delta(+) ratio was mainly observed in a CD8 alpha alpha(+) subset of IEL. IEC from NT(+) diet-fed mice produced a higher level of IL-7, which is important in the development of TCR gamma delta(+) IEL, than those from control diet-fed mice. The expression levels of IL-7 and IL-2 receptors on IEL were not different between the two dietary groups. Our findings suggest that the increased population of a TCR gamma delta(+) IEL subset by feeding nucleotides may be caused by the increased production of IL-7 by IEC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available