Journal
BIOLOGICAL TRACE ELEMENT RESEARCH
Volume 149, Issue 1, Pages 10-15Publisher
HUMANA PRESS INC
DOI: 10.1007/s12011-012-9396-7
Keywords
Arsenic; Environmental level; Prenatal exposure; Birth size
Funding
- Japan Society for the Promotion of Science [18406026]
- foundation for Scientific Research and Technology, Health Bureau of Dalian [2007-73]
- Grants-in-Aid for Scientific Research [23406024, 18406026] Funding Source: KAKEN
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To evaluate prenatal exposure to arsenic in the general population and its effects on birth size, we conducted a cross-sectional study in Dalian, China. Arsenic concentration in maternal and cord blood was detected by inductively coupled plasma-mass spectrometry and its effects on birth size were analyzed by multivariate analysis and multiple linear regression analysis. Arsenic concentrations in cord blood were significantly lower than those in maternal blood. A significant positive correlation was shown between maternal and cord blood arsenic concentrations. Maternal arsenic concentration was negatively associated with birth weight, height and chest circumference, and fetal arsenic concentration was negatively associated with head circumference. Our results indicate that arsenic exposure at environmental levels in uterus may pose adverse effects on fetal development.
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