Journal
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
Volume 9, Issue 4, Pages 435-439Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00041552-200007000-00016
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The role of the endothelin-B receptor in vascular homeostasis is controversial because the receptor has both presser and depressor effects in vivo. One potential depressor mechanism of endothelin-B activation is through the promotion of natriuresis and diuresis in the renal tubule. Recent studies demonstrate that rodents genetically deficient for the endothelin-B exhibit sodium-dependent hypertension due to an absence of tonic inhibition of the epithelial sodium channel in the distal nephron. These studies suggest that the predominant role of endothelin-B receptors in the basal physiologic state may be to regulate renal sodium excretion relative to the level of oral salt intake. Curr Opin Nephrol Hypertens 9:435-439. (C) 2000 Lippincott Williams & Wilkins.
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