Journal
BIOLOGICAL TRACE ELEMENT RESEARCH
Volume 151, Issue 2, Pages 234-239Publisher
HUMANA PRESS INC
DOI: 10.1007/s12011-012-9554-y
Keywords
Nickelchloride; IL-2; IL-4; IL-6; IL-10; IFN-gamma; TNF-alpha; Serum; Broiler
Funding
- program for Changjiang scholars and innovative research team in university [IRT 0848]
- Education Department and Scientific department of Sichuan Province [09ZZ017]
Ask authors/readers for more resources
Cytokines are immunoregulatory proteins which play an important role in the immune system. The purpose of this study was to examine the serum cytokine contents including interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-10 (IL-10), interferon gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) induced by dietary nickel chloride in broilers by enzyme-linked immunospecific assay. A total of 240 one-day-old avian broilers were divided into four groups and fed on a corn-soybean basal diet as control diet or the same basal diet supplemented with 300, 600, and 900 mg/kg of nickel chloride. During the experimental period of 42 days, the results showed that the serum IL-2, IL-4, IL-6, IL-10, IFN-gamma and TNF-alpha contents were lower (p < 0.05 or p < 0.01) in the 300, 600, 900 mg/kg groups than those in the control group. It was concluded that dietary nickel chloride in the range of 300 to 900 mg/kg could reduce the serum cytokine contents, which could finally impact the immune function in broilers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available