Journal
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Volume 50, Issue 1, Pages 27-46Publisher
ELSEVIER
DOI: 10.1016/S0939-6411(00)00090-4
Keywords
pH-sensitive hydrogels; temperature-sensitive hydrogels; application in drug delivery; drug release; polymer network structure
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Funding
- NIGMS NIH HHS [GM 56231, GM 43337] Funding Source: Medline
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The availability of large molecular weight protein- and peptide-based drugs due to the recent advances in the field of molecular biology has given us new ways to treat a number of diseases. Synthetic hydrogels offer a possibly effective and convenient way to administer these compounds. Hydrogels are hydrophilic, three-dimensional networks, which are able to imbibe large amounts of water or biological fluids, and thus resemble, to a large extent, a biological tissue. They are insoluble due to the presence of chemical (tie-points, junctions) and/or physical crosslinks such as entanglements and crystallites. These materials can be synthesized to respond to a number of physiological stimuli present in the body, such as pH, ionic strength and temperature. The aim of this article is to present a concise review on the applications of hydrogels in the pharmaceutical field, hydrogel characterization and analysis of drug release from such devices. (C) 2000 Elsevier Science B.V. All rights reserved.
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