Journal
PEPTIDES
Volume 21, Issue 7, Pages 1051-1062Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0196-9781(00)00243-6
Keywords
nociceptin; orphanin FQ; nocistatin; food intake; water intake; ORL1 receptor agonists; ORL1 receptor antagonists
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Nociceptin/orphanin FQ (NC), the endogenous ligand of the opioid receptor-like 1 (ORL1) receptor, has been reported to stimulate feeding in rats. The present article reviews the studies so far published on the effect of NC on food intake and reports new findings concerning the sensitivity of brain regions to the hyperphagic effect of NC in rats. The results obtained indicate that the hypothalamic arcuate nucleus is the most sensitive site among the brain regions so far investigated. On the basis of these findings and of the neurochemical and electrophysiological effects of NC, possible mechanisms of action and possible interactions with other neurotransmitter systems affecting feeding are discussed. (C) 2000 Elsevier Science Inc. All rights reserved.
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