Journal
BIOLOGICAL TRACE ELEMENT RESEARCH
Volume 145, Issue 1, Pages 66-70Publisher
HUMANA PRESS INC
DOI: 10.1007/s12011-011-9168-9
Keywords
Vanadium; Diabetes; Focal cerebral ischemia; Insulin; Cerebrovascular disease
Funding
- Ministry of Science and Technology [2009ZX09502-017]
- Program for New Century Excellent Talents in University [NCET-10-0273]
- Beijing Nova Program [2010B035]
- Key Laboratory of Mental Health
- Chinese Academy of Sciences [KSCX2-YW-R-254, KSCX2-EW-Q-18, KSCX2-EW-J-8]
- IPCAS [08CX043004]
- NNSF [30800301]
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There is now substantial epidemiological evidence that diabetes is a risk factor for cerebrovascular disease. The protection by vanadium from focal cerebral ischemia in diabetic rats was studied in this paper. Rats with streptozotocin-induced diabetes were subjected to middle cerebral artery occlusion followed by 4 weeks of administration of 0.6 mg/ml sodium orthovanadate in drinking water. Vanadium significantly improved the outcome in diabetic rats after cerebral ischemia and reperfusion in terms of neurobehavioral function. Vanadium reduces brain damage in streptozotocin-induced diabetic rats by imitating action of insulin.
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