4.5 Article

The effect of anticonvulsant drugs on blood levels of methotrexate

Journal

JOURNAL OF NEURO-ONCOLOGY
Volume 48, Issue 3, Pages 249-250

Publisher

KLUWER ACADEMIC PUBL
DOI: 10.1023/A:1006404825356

Keywords

anticonvulsant drugs; chemotherapy; gliomas

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The reduced bioavailability of chemotherapeutic agents is one of the reasons that explains the limited efficacy of adjuvant chemotherapy in high grade glioma patients. We report how even the results of high dose sequential chemotherapy can be influenced by antiepileptic drugs.

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