Journal
MICROBIOLOGY-UK
Volume 146, Issue -, Pages 1671-1677Publisher
SOC GENERAL MICROBIOLOGY
DOI: 10.1099/00221287-146-7-1671
Keywords
colicins; positive selection; evolution; plasmid; Yanomama Indians
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Funding
- NIGMS NIH HHS [T32 GM145304, GM08353, GM07315] Funding Source: Medline
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Two evolutionary mechanism have been proposed in the process of protein diversification of the large family of antimicrobial toxins of Escherichia coli, known a the colicins. Data from previous studies suggest that the relatively rare nuclease colicins appear to diversify primarily through the action of positive selection. Whilst the more abundant pore-former colicins appear to diversify through the action of recombination. The complete DNA sequence of the newly characterized colicin plasmid, pCo-Let, isolated from a Yanomama Indian of South America, is presented here. This plasmid encodes a newly identified pore-former colicin, colicin Y. DNA and protein sequence comparisons of the colicin Y gene cluster and the encoded proteins with those of published pore-former colicins provide the first evidence that positive selection may also act to increase pore-former colicin diversity.
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