Journal
DEVELOPMENTAL BIOLOGY
Volume 223, Issue 1, Pages 70-76Publisher
ACADEMIC PRESS INC
DOI: 10.1006/dbio.2000.9713
Keywords
Smad; TGF beta; BMP; Caenorhabditis elegans; pattern formation; cell size
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Funding
- NICHD NIH HHS [HD34165] Funding Source: Medline
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A TGF beta signal transduction cascade controls body size and male tail morphogenesis in the nematode Caenorhabditis elegans. We have analyzed the function of the sma-3 Smad gene, one of three Smad genes that function in this pathway. Null mutations in sma-3 are at least as severe as null mutations in the ligand and type I receptor genes, dbl-1 and sma-6, indicating that the other Smads do not function in the absence of SMA-3. Furthermore, null mutations in sma-3 do not cause defects in egg laying or in regulation of the developmentally arrested dauer larva stage, indicating no overlapping function with another C. elegans TGF beta signaling pathway. The sma-3 gene is widely expressed at all developmental stages in hermaphrodites and males. The molecular lesions associated with eight sma-3 alleles of varying severity have been determined. The missense mutations cluster in two previously identified regions important for Smad function. (C) 2000 Academic Press.
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