Journal
GASTROINTESTINAL ENDOSCOPY
Volume 52, Issue 1, Pages 27-32Publisher
MOSBY, INC
DOI: 10.1067/mge.2000.106112
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Background: A nonrandomized trial of Helicobacter pylori eradication was conducted in patients with endoscopically diagnosed gastric adenoma to determine the long-term effect of antimicrobial treatment on progression of the adenoma. Methods: Of 64 patients with an endoscopically diagnosed gastric adenoma and H pylori infection, 32 were treated with omeprazole and antibiotics to eradicate the infection, and 32 were not. Results: During 2 years of follow-up, 4 (12.5%) of the 32 patients in the untreated group developed an early stage, intestinal-type gastric cancer, whereas no gastric cancer was found in the 32 patients in the treated group. Conclusion: H pylori eradication may inhibit progression of gastric adenoma to carcinoma.
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