Journal
NATURE MEDICINE
Volume 6, Issue 7, Pages 790-796Publisher
NATURE AMERICA INC
DOI: 10.1038/77521
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Funding
- NHLBI NIH HHS [HL03174, HL62995] Funding Source: Medline
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Apoptosis of smooth muscle cells is a common feature of vascular lesions but its pathophysiological significance is not known. We demonstrate that signals initiated by regulated Fas-associated death domain protein overexpression in rat vascular smooth muscle cells in the carotid artery induce expression of monocyte-chemoattractant protein-1 and interleukin-8, and cause massive immigration of macrophages in vivo. These chemokines, and a specific set of other pro-inflammatory genes, are also upregulated in human vascular smooth muscle cells during Fas-induced apoptosis, in part through a process that requires interleukin-1 alpha activation. Induction of a proinflammatory program by apoptotic vascular smooth muscle cells may thus contribute to the pathogenesis of vascular disease.
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