Journal
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM
Volume 35, Issue 1, Pages 21-28Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0306-3623(01)00086-6
Keywords
Cudrania tricuspidata; nitric oxides; inducible nitric oxide synthase; inducible nitric oxide synthase activity; nuclear factor-kappa B; inflammation; RAW 264.7 macrophages
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It was found that the production of nitric oxide (NO) by RAW 264.7 macrophages stimulated with interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) could be markedly inhibited by the ethyl-acetate-soluble fraction of 80% aqueous methanolic extract of stem barks of Cudrania tricuspidata (EACT). Inhibition of NO production was achieved by reducing inducible nitric oxide synthase (iNOS) expression at protein and mRNA levels and by inactivating nuclear factor-kappaB (NF-kappaB), but not by inhibiting iNOS activity. Thus, further phytochemical and pharmacological studies may lead to isolation and structural identification of an inhibitor of iNOS from C tricuspidata, which has been used as a traditional medicine for curing inflammation. (C) 2001 Elsevier Science Inc. All rights reserved.
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