Journal
JOURNAL OF MAGNETIC RESONANCE
Volume 145, Issue 1, Pages 24-36Publisher
ACADEMIC PRESS INC
DOI: 10.1006/jmre.2000.2059
Keywords
magnetization transfer; cross-relaxation; quantitative imaging; magnetic resonance imaging
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A method for analyzing general pulsed magnetization transfer (MT) experiments in which off-resonance saturation pulses are interleaved with on-resonance excitation pulses is presented. We apply this method to develop a steady-state signal equation for MT-weighted spoiled gradient echo sequences and consider approximations that facilitate its rapid computation. Using this equation, we assess various experimental designs for quantitatively imaging the fractional size of the restricted pool, cross-relaxation rate, and T-1 and T-2 relaxation times of the two pools in a binary spin bath system. From experiments on agar gel, this method is shown to reliably and accurately estimate the exchange and relaxation properties of a material in an imaging context, suggesting the feasibility of using this technique in vivo. (C) 2000 Academic Press.
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