Journal
BIOLOGICAL TRACE ELEMENT RESEARCH
Volume 134, Issue 1, Pages 68-78Publisher
HUMANA PRESS INC
DOI: 10.1007/s12011-009-8448-0
Keywords
Mice; Lanthanoid; Lung; Reactive oxygen specise; Antioxidant enzymes
Funding
- National Natural Science Foundation of China [30800068]
- Junzheng Scholar Foundation
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This study was performed with the objective of assessing the antioxidant response of the lung of mice to different rare earths. LaCl3, CeCl3, and NdCl3 at a higher dose of 20 mg/kg body weight were injected into the nasal cavity of ICR mice for consecutive 14 days, respectively. The increase of pulmonary lipids peroxide produced by Ln suggested an oxidative attack that was activated by a reduction of antioxidative defense mechanisms as measured by analyzing the activities of superoxide dismutase, catalase, ascorbate peroxidase, and total antioxidant capacity, as well as antioxidant levels such as glutathione and ascorbic acid, which were greatest in Ce3+ treatment, medium in Nd3+, and least in La3+. It implied that the antioxidative responses of lung may be involved in 4f shell and alternable valence properties of Ln-induced lung toxicity.
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