Journal
FASEB JOURNAL
Volume 14, Issue 10, Pages 1375-1379Publisher
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.14.10.1375
Keywords
nerve growth factor; dorsal root ganglia; PCD; IP(3)R3 expression
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Funding
- NIDA NIH HHS [DA-00074] Funding Source: Medline
- NIMH NIH HHS [MH-18501] Funding Source: Medline
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Mechanisms accounting for the cellular entry of calcium that mediates cellular proliferation and apoptosis have been obscure. Previously we reported selective augmentation of type 3 inositol (1,4,5) trisphosphate receptors (IP(3)R3) in lymphocytes undergoing programmed cell death, which was prevented by antisense constructs to IP(3)R3. We now report increases in mRNA and protein levels for IP(3)R3 associated with cell death in several apoptotic paradigms in diverse tissues. Elevations of IP,RS occur during developmental apoptosis in early postnatal cerebellar granule cells, dorsal root gang-lia, embryonic hair follicles, and intestinal villi. Neurotoxic damage elicited by the glutamate agonist kainate is also associated with IP(3)R3 augmentation. In chick dorsal root ganglia neurons undergoing apoptosis due to deprivation of nerve growth factor, levels of IP(3)R3 are selectively increased and cell death is selectively prevented by antisense oligonucleotides to IP(3)R3. Thus, IP(3)R3 appears to participate actively in cell death in a diversity of tissues.
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