Journal
BIOLOGICAL REVIEWS
Volume 94, Issue 2, Pages 503-516Publisher
WILEY
DOI: 10.1111/brv.12464
Keywords
autophagy; development; life cycle; mammal; physiological roles
Categories
Funding
- National Key R&D Program of China [2018YFA0108402]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA16030302]
- National Natural Science Foundation of China Program [31720103907, 31621004, 31570995]
- Key Research Program of the Chinese Academy of Sciences [ZDRW-ZS-2017-5]
- National Thousand Young Talents Program
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Autophagy is primarily an efficient intracellular catabolic pathway used for degradation of abnormal cellular protein aggregates and damaged organelles. Although autophagy was initially proposed to be a cellular stress responder, increasing evidence suggests that it carries out normal physiological roles in multiple biological processes. To date, autophagy has been identified in most organs and at many different developmental stages, indicating that it is not only essential for cellular homeostasis and renovation, but is also important for organ development. Herein, we summarize our current understanding of the functions of autophagy (which here refers to macroautophagy) in the mammalian life cycle.
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