Journal
JOURNAL OF CLINICAL IMMUNOLOGY
Volume 20, Issue 4, Pages 240-249Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1023/A:1006659401385
Keywords
aging; B cells; B cell repertoire; clonal B cell expansions
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Funding
- NIA NIH HHS [AG-14669] Funding Source: Medline
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The antibody repertoire changes with age. This change reflects, in part, the age-associated impairment in the production of a diverse population of naive B cells in the bone marrow and, in parr, by the decreased diversification of B cells in the germinal center where affinity maturation and isotype switching takes place. B cell number is strictly regulated and despite the decreased output of B cells by the bone marrow does not decline during aging. Self-renewal of peripheral B cells is sufficient to assure the stability of peripheral B cell number. However, when B cell production is stressed as, for example, Following drug-induced lymphopenia, the rate of recovery of B cell number as well as of B cell diversity is compromised in old compared to young mice. Finally, aging is associated with the appearance of B cell clonal expansions which not only limit the diversity of the B cell repertoire but very likely give rise to monoclonal serum immunoglobulins and B cell neoplasms.
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