Journal
INFECTION AND IMMUNITY
Volume 68, Issue 7, Pages 4323-4326Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.68.7.4323-4326.2000
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- NIAID NIH HHS [5 T AI07172, AI27342, T32 AI007172] Funding Source: Medline
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Invasin-mediated invasion of host cells by the pathogen Yersinia enterocolitica was shown to be affected by flagellar-dependent motility. Motility appears to be required to ensure the bacterium migrates to and contacts the host cell. Nonmotile strains of Y. enterocolitica were less invasive than motile strains, but the reduction in Invasion could be overcome by artificially bringing the bacteria into host cell contact by centrifugation. Mutations in known regulatory genes of the flagellar regulon, flhDC and fliA, resulted in less inv expression but did not have a significant effect on invasin levels. However, invasin levels were reduced for strains that harbored flhDC on a multicopy plasmid, apparently as a result of increased proteolysis of invasin.
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