Journal
BONE MARROW TRANSPLANTATION
Volume 26, Issue 2, Pages 161-167Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bmt.1702472
Keywords
allogeneic bone marrow transplant; tacrolimus; FK506; children; graft-versus-host disease; peripheral blood stem cell transplant
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Currently, limited data exist on the role of tacrolimus (FK506) in pediatric allogeneic marrow transplantation. Forty-one patients who received tacrolimus as prophylaxis were reviewed, with a median age of 9 years (range 0.2-16 years). Twenty-one patients underwent related donor transplants and 20 underwent unrelated donor transplants. All patients received tacrolimus beginning the day Drier to transplant at a dose of 0.03 mg/kg/day by continuous i.v. infusion, When clinically possible, patients were switched to oral therapy in two divided doses, at four times the intravenous dose, Tacrolimus levels were monitored twice a week, and dosages adjusted to maintain serum levels 5-15 ng/ml, Common adverse effects included hypomagnesemia (98 %), hypertension (49%), nephrotoxicity (34%), and tremors (32 %), Less common side-effects (<10% cases) included seizures and hyperglycemia. The median time to ANC recovery (ANC >500 x 10(6)/l) was 15 days, For the related donor group, the incidence of grade II-IV acute GVHD was 33%, and grade III-IV GVHD 19%. For the unrelated donor group, the incidence of grade II-IV acute GVHD was 55%, and grade III-IV GVHD 30%. Overall, tacrolimus therapy was well tolerated as prophylaxis for acute? GVHD in pediatric patients undergoing allogeneic transplantation.
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