Journal
CELL AND TISSUE RESEARCH
Volume 301, Issue 1, Pages 163-171Publisher
SPRINGER
DOI: 10.1007/s004410000179
Keywords
multiple sclerosis; autoimmune disease; apoptosis; CD95; T cell; therapy
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Several recent studies have provided evidence that apoptosis is an important feature in the pathogenesis of multiple sclerosis (MS), an autoimmune disease of the central nervous system. Apoptosis presumably plays a role in the immunoregulation via activation-induced T-cell death (AICD) and in local processes of tissue damage. In this review the dual role of apoptosis in the MS pathogenesis and its relevance regarding therapeutic concepts is discussed.
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