Journal
BIOLOGICAL RESEARCH FOR NURSING
Volume 10, Issue 1, Pages 44-53Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1099800408319056
Keywords
wound infection; diabetic foot ulcers; amputation; osteomyelitis
Categories
Funding
- NINR NIH HHS [1R01 NR 009448-01A2, R01 NR009448] Funding Source: Medline
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The identification and diagnosis of diabetic foot ulcer (DFU) infections remains a complex problem. Because inflammatory responses to microbial invasion may be diminished in persons with diabetes, clinical signs of infection are often absent in persons with DFUs when infection is limited to localized tissue. In the absence of these clinical signs, microbial load is believed to be the best indicator of infection. Some researchers, however, believe microbial load to be insignificant and type of organism growing in the ulcer to be most important. Previous studies on the microbiology of DFUs have not provided enough evidence to determine the microbiological parameters of importance. Infection-related complications of DFUs include wound deterioration, osteomyelitis, and amputation. Risk factors for amputation include age, peripheral vascular disease, low transcutaneous oxygen, smoking, and poor glycemic control. These risk factors are best measured directly with physiological measures of arterial perfusion, glycemic control, sensory neuropathy, plantar pressures, and activity level and by controlling off-loading. DFU bioburden has not been examined as a risk factor for infection-related complications. To address the relationship between wound bioburden and the development of infection-related complications in DFUs, tightly controlled prospective studies based on clearly defined, valid measures of wound bioburden and wound outcomes are needed. This article reviews the literature and proposes a model of hypothesized relationships between wound bioburden-including microbial load, microbial diversity, and pathogenicity of organisms-and the development of infection-related complications.
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