Journal
MICROBIOLOGY-SGM
Volume 146, Issue -, Pages 1547-1553Publisher
MICROBIOLOGY SOC
DOI: 10.1099/00221287-146-7-1547
Keywords
bacitracin; bacA; undecaprenol kinase; Staphylococcus aureus; Streptococcus pneumoniae
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Homologues of Escherichia coli bacA. encoding extremely hydrophobic proteins, were identified in the genomes of Staphylococcus aureus and Streptococcus pneumoniae. Allelic replacement mutagenesis demonstrated that the gene is not essential for in vitro growth in either organism, and the mutants showed no significant changes in growth rate or morphology. The Staph. aureus bacA mutant showed slightly reduced virulence in a mouse model of infection and an eightfold increase in bacitracin susceptibility. However, a Strep. pneumoniae bacA mutant was highly attenuated in a mouse model of infection, and demonstrated an increase in susceptibility to bacitracin of up to 160 000-fold. These observations are consistent with the previously proposed role of BacA protein as undecaprenol kinase.
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