Examining noise sources at the single-molecule level:: 1/f noise of an open maltoporin channel

We have studied the phenomenological origin of 1/f noise in a solute-specific bacterial inn channel, maltoporin. We show that after excision of small, but resolvable stepwise changes in the recordings of the current through a single open channel, the 1/f noise component disappears and the channel exhibits noise that is white below 100 Hz. Combined with results of a recent noise study of several bacterial porins, our observations suggest that 1/f noise is caused by the equilibrium conductance fluctuations related to the conformational flexibility of the channel pore structural constituents.