Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 97, Issue 14, Pages 7823-7828Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.97.14.7823
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Funding
- NIAMS NIH HHS [R01 AR044197, AR44197] Funding Source: Medline
- NINDS NIH HHS [R01 NS023346, NS23346] Funding Source: Medline
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Ca2+ sparks are brief, localized elevations of myoplasmic [Ca2+] caused by release of increments of Ca2+ via sarcoplasmic reticulum Ca2+ release channels in muscle. The properties of individual sparks provide information regarding the opening of sarcoplasmic reticulum Ca2+ channels within functioning cells. Here we use high-speed confocal microscopy to show that individual Ca2+ sparks activated by membrane depolarization in single frog skeletal muscle fibers can be terminated prematurely by repolarization. Thus, either voltage sensor deactivation on repolarization or release channel inactivation during continued depolarization can terminate the Ca2+ release channel activity underlying voltage-activated Ca2+ sparks in skeletal muscle.
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