Journal
ONCOGENE
Volume 19, Issue 29, Pages 3225-3234Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1203665
Keywords
Survivin; Cdk; INK4a; p27; cell cycle progression
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Survivin is observed uniquely in tumor cells and developmental cells, which undergo either inappropriate or programmed cell growth, In the current study, we investigated the influence of Survivin on cell cycle, Overexpression of Survivin resulted in accelerated S phase shift, resistance to G1 arrest, and activated Cdk2/Cyclin E complex leading Rb phosphorylation, In addition, nuclear translocation of Survivin followed by an interaction with Cdk4 was detected. Interestingly, Survivin nuclear translocation coincided with S phase shift, and prevention of nuclear transport suppressed Survivin nuclear translocation and S phase shift. Further, we also observed that Survivin competitively interacted with the Cdk4/p16(INK4n) complex in a cell free system and in vivo. These results suggest that Survivin initiates the cell cycle entry as a result of nuclear translocation followed by an interaction with Cdk4.
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