Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 399, Issue 2-3, Pages 165-169Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-2999(00)00374-5
Keywords
cocaine; amphetamine; dorsal hem; hyperalgesia
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Funding
- NINDS NIH HHS [NS39646, NS18710] Funding Source: Medline
- PHS HHS [3811] Funding Source: Medline
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Immunohistochemical studies with the use of an antiserum against the cocaine- and amphetamine-regulated transcript (CART) peptide-(55-102) showed an abundance of CART-immunoreactive fibers in the mouse dorsal horn laminae I and II. A few CART-positive somata were scattered in the dorsal horn and around the central canal. Intrathecal injection of the CART peptide-(55-102) at doses 3, 10 and 100 ng caused a dose-dependent and significant decrease of paw withdrawal latency; whereas, saline injection was without significant effect. Our results provide the first evidence that CART-immunoreactive fibers are present in the dorsal horn and that the peptide administered intrathecally produces hyperalgesia, as assessed by paw withdrawal latency in mice. (C) 2000 Elsevier Science B.V. All rights reserved.
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