Journal
SCIENCE
Volume 289, Issue 5476, Pages 107-110Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.289.5476.107
Keywords
-
Categories
Funding
- NIGMS NIH HHS [R37-GM 34985] Funding Source: Medline
- NIMH NIH HHS [MH44651] Funding Source: Medline
Ask authors/readers for more resources
In Neurospora crassa, white collar 1 (WC-1), a transcriptional activator and positive clock element, is rhythmically expressed from a nonrhythmic steady-state pool of wc-1 transcript, consistent with posttranscriptional regulation of rhythmicity. Mutations in frq influence both the level and periodicity of WC-1 expression, and driven FRQ expression not only depresses its own endogenous levels, but positively regulates WC-1 synthesis with a lag of about 8 hours, a delay similar to that seen in the wild-type clock. FRQ thus plays dual roles in the Neurospora clock and thereby, with WC-1, forms a second feedback loop that would promote robustness and stability in this circadian system. The existence also of interlocked loops in Drosophila melanogaster and mouse clocks suggests that such interlocked loops may be a conserved aspect of circadian timing systems.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available