Journal
BIOLOGICAL PSYCHOLOGY
Volume 100, Issue -, Pages 50-55Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.biopsycho.2014.05.001
Keywords
Cortisol; HPA axis; Depression; Rumination; Emotion regulation; Experimental
Funding
- National Institute of Mental Health [F31MH086246]
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Depressive rumination - a central characteristic of Major Depressive Disorder (MDD) - is a maladaptive emotion regulation strategy that prolongs sad mood and depressive episodes. Considerable research demonstrates the emotional and behavioral consequences of depressive rumination, yet few studies investigate its effect on neuroendocrine functioning. The current study examined the effect of an emotion regulation manipulation on the trajectory of cortisol concentrations among individuals with MDD and healthy controls (CTL). Sadness was induced via forced failure. Participants then were randomly assigned to a depressive rumination or distraction emotion regulation induction. MDDs in the rumination condition exhibited less cortisol decline compared to MDDs in the distraction condition and compared to CTLs in either condition. Findings suggest that depressive rumination alters the trajectory of cortisol secretion in MDD and may prolong cortisol production. Results thereby provide important in sights into the interaction of biological and psychological factors through which distress contributes to MDD. (C) 2014 Elsevier B. V. All rights reserved.
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