Journal
BIOLOGICAL PSYCHOLOGY
Volume 103, Issue -, Pages 7-14Publisher
ELSEVIER
DOI: 10.1016/j.biopsycho.2014.07.016
Keywords
fMRI; Reward system; Individual differences; Monetary incentive delay task
Funding
- National Institutes of Health [R21 AA 01 7314, R01 DA036216, P30 N5057091, P30 N5076408]
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Although altered brain activation during reward tasks has been found in a number of heritable psychiatric disorders and health outcomes, the familial nature of reward-related brain activation remains unexplored. In this study, we investigated the degree to which the magnitude of mesocorticolimbic reward system signal intensities in anticipation of reward during the monetary incentive delay (MID) task was similar within 46 pairs of adolescent, monozygotic twins. Significant within-pair correlations in brain activation during anticipation of gain were found in one third of the 18 reward-related regions investigated. These regions were the right nucleus accumbens, left and right posterior caudate, right anterior caudate, left insula, and anterior cingulate cortex. This serves as evidence for a shared familial contribution to individual differences in reward related brain activity in certain key reward processing regions. (C) 2014 Elsevier B.V. All rights reserved.
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