Journal
SCIENCE
Volume 289, Issue 5477, Pages 310-313Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.289.5477.310
Keywords
-
Categories
Funding
- NIAID NIH HHS [AI35109, AI16567, AI46351] Funding Source: Medline
Ask authors/readers for more resources
Although the diploid fungus Candida albicans, a human pathogen, has been thought to have no sexual cycle. it normally possesses mating-type-like orthologs (Mn) of both of the Saccharomyces cerevisiae mating-type genes (MAT) a and alpha. When strains containing only MTLa or MTL alpha were constructed by the Loss of one homolog of chromosome 5, the site of the MTL Loci, MTLa and MTL alpha strains mated, but like mating types did not. Evidence for mating included formation of stable prototrophs from strains with complementing auxotrophic markers; these contained both MTL alleles and molecular markers from both parents and were tetraploid in DNA content and mononucleate.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available