Journal
NEUROREPORT
Volume 11, Issue 10, Pages 2213-2216Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200007140-00030
Keywords
cdk5; expression pattern; p35; p39; synapse
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Funding
- NIGMS NIH HHS [GM53049] Funding Source: Medline
- NINDS NIH HHS [F32 NS10655] Funding Source: Medline
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The expression and kinase activity of cyclin dependent kinase 5 (cdk5) parallels the extent of neuronal differentiation. Cdk5 activity has been shown to be required for neurite outgrowth, cortical lamination and the overall development of the nervous system. p35 was identified as the first regulatory activator of cdk5 whose presence is required for cdk5 activation. p39 is a homolog of p35, and the only one identified in mammals thus far. We show here that p39 expression is mainly postnatal. In addition, we provide evidence for the presence of p39 at synaptic junctions through co-fractionation experiment, electron microscopy and immunostaining. The temporal and spatial expression of p39 indicate a possible role of the p39/cdk5 kinase at the synapse. NeuroReport 11:2213-2216 (C) 2000 Lippincott Williams & Wilkins.
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