Journal
SCIENCE
Volume 289, Issue 5477, Pages 265-270Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.289.5477.265
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- NIGMS NIH HHS [5T32GM07365] Funding Source: Medline
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Mutation at the mouse progressive ankylosis (ank) locus causes a generalized, progressive form of arthritis accompanied by mineral deposition, formation of bony outgrowths, and joint destruction. Here, we show that the ank Locus encodes a multipass transmembrane protein (ANK) that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. A highly conserved gene is present in humans and other vertebrates. These results identify ANK-mediated control of pyrophosphate levels as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals.
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