Journal
NEUROREPORT
Volume 11, Issue 10, Pages 2217-2222Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200007140-00031
Keywords
amiloride; CNS; degenerins; protons; rat
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Acid-sensing ion channels (ASICs) are members of the epithelial sodium channel (ENaC)-degenerin family of two-pass transmembrane segment protein subunits which form multimeric cation channels. Members of the ENaC-degenerin family are gated by stimuli as diverse as protons, peptides and mechanical distension. Here we describe a new member of the family, SPASIC or ASIC 4 (spinal cord ASIC) which is expressed throughout the central nervous system in an overlapping population of neurons that also express the ASIC subunit MDEG2. ASIC-4 which shows 44% identify with ASIC is developmentally regulated and expressed in a subset of sensory neurons as well as in the CNS. However, despite the strong homology with ASIC, the ASIC-4 transcript does not encode a proton gated cation channel. NeuroReport 11:2217-2222 (C) 2000 Lippincott Williams & Wilkins.
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