Journal
JOURNAL OF IMMUNOLOGY
Volume 165, Issue 2, Pages 860-868Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.165.2.860
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Funding
- NCI NIH HHS [CA53382, CA99-00542V-10051, CA59713] Funding Source: Medline
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IL-2 is the major autocrine and paracrine growth factor produced by T cells upon T cell stimulation. The inducible expression of IL-2 is highly regulated by multiple transcription factors, particularly AP-1, which coordinately activate the promoter. Described here is the ability of the novel basic leucine zipper protein p21(SNFT) to repress AP-1 activity and IL-2 transcription. A detailed analysis of the repression by p21(SNFT) repression on the IL-2 promoter distal NF-AT/AP-1 site demonstrates that it can bind DNA with NF-AT and Jun, strongly suggesting that it represses NF-AT/AP-1 activity by competing with Fos proteins for Jun dimerization, The importance of this repression is that p21(SNFT) inhibits the trans-activation potential of protein complexes that contain Jun, thereby demonstrating an additional level of control for the highly regulated, ubiquitous AP-1 transcription factor and the IL-2 gene.
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