Synthesis and characterization of a diruthenium-ibuprofenato complex -: Comparing its anti-inflammatory activity with that of a copper(II)-ibuprofenato complex

The ibuprofen complex of diruthenium(II,III) was prepared and characterized by electronic (UV-Vis) and vibrational (FTIR spectroscopies and thermogravimetry. The copper(II)-ibuprofenato complex was prepared by a different rc,ute from that described in the literature. Both complexes were tested in vivo for anti-inflammatory activity. Oral administration of the two complexes inhibited development of carrageenin-induced edema in rats, this inhibition being similar to that observed for oral administration of the parent drug (free ibuprofen). However, gastric irritation was lower as compared to that of ibuprofen. Diruthenium-ibuprofenato exhibited a protective effect at light intensity ulceration while the copper-ibuprofenato complex was more effective in the:protection of severe intensity ulceration. (C) 2000 Elsevier Science S.A. All rights reserved.