Journal
SCIENCE
Volume 289, Issue 5478, Pages 438-441Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.289.5478.438
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Funding
- NICHD NIH HHS [T32HD07477, HD32551] Funding Source: Medline
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The developmental mechanisms specifying digital identity have attracted 30 years of intense interest, but still remain poorly understood, Here, through experiments on chick foot development, we show digital identity is not a fixed property of digital primordia. Rather, digital identity is specified by the interdigital mesoderm, demonstrating a patterning function for this tissue before its regression. More posterior interdigits specify more posterior digital identities, and each primordium will develop in accordance with the most posterior cues received. Furthermore, inhibition of interdigital bone morphogenetic protein (BMP) signaling can transform digit identity, suggesting a role for BMPs in this process.
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