Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 274, Issue 1, Pages 32-36Publisher
ACADEMIC PRESS INC
DOI: 10.1006/bbrc.2000.3087
Keywords
dopamine; dopa; glutathione transferase; o-quinones; aminochrome; dopachrome; 5-S-cysteinyl-dopa; 5-S-cysteinyldopamine; neuromelanin
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Human glutathione transferase M2-2 prevents the formation of neurotoxic aminochrome and dopachrome by catalyzing the conjugation of dopamine and dopa o-quinone with glutathione. NMR analysis of dopamine and dopa o-quinone-glutathione conjugates revealed that the addition of glutathione was at C-5 to form 5-S-glutathionyl-dopamine and 5-S-glutathionyldopa, respectively. Both conjugates were found to be resistant to oxidation by biological oxidizing agents such as O-2, H2O2, and O-2(.-), and the glutathione transferase-catalyzed reaction can therefore serve a neuroprotective antioxidant function. (C) 2000 Academic Press.
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