Study on highly sensitive potentiometric IgG immunosensor

A novel potentiometric immunosensor for detection of immunogloblin G (IgG) has been developed by means of covalent immobilization of anti-immunogloblin G on a silver (Ag) electrode. The detection is based on the change in the electric potential before and after the antigen-antibody reaction. Tests relating to the detection of IgG demonstrate that the immunosensor exhibits a high level of sensitivity, stability and reproducibility, the linear response range was 0.2-1.2 ng/ml for IgG solution and the lifetime was more than 28 days. (C) 2000 Elsevier Science S.A. All rights reserved.